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Phenotypes Associated with This Genotype
Genotype
MGI:3701875
cx2
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Genetic
Background		 B6.129P-H2-D1b-tm1Bpe H2-K1b-tm1Bpe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytotoxic T cell physiology ( J:118960 )
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection

hematopoietic system
abnormal cytotoxic T cell physiology ( J:118960 )
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory