Analysis Tools
growth/size/body
weight loss
(
J:119004
)
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• mice show a statistical loss of body weight starting at 8 months
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hematopoietic system
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• hematologic parameters are slightly increased during the first months of life, but return to normal values at 6 months
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• iron content in spleen is markedly decreased vs wild-type
• at 8 months, splenic iron levels are decreased about 3-fold (273 ug/ g tissue vs 784 ug/g in wild-type)
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homeostasis/metabolism
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• iron content in spleen is markedly decreased vs wild-type
• at 8 months, splenic iron levels are decreased about 3-fold (273 ug/ g tissue vs 784 ug/g in wild-type)
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• serum iron increases at 2 months in mutants and remains constant
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• serum ferritin levels increase in parallel to liver iron increase
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• at 4 months of age, massive iron accumulation is observed in liver and pancreas of mutants; significant iron is detected in the heart compared to wild-type
• iron accumulates in liver parenchymal cells (hepatocytes) with sparing of the macrophages; iron deposition is more prominent in the centrolobular areas
• liver iron content is elevated 5-fold in mutants at 2 months of age, while at 8 months, liver iron is increased ~15-fold over controls
• at 8 months, mutants have ~30-fold increase in pancreatic iron content (2056 ug/g tissue vs 66 ug/g tissue in wild-type)
• at 8 months of age, heart iron content is 5.5-fold higher in mutants (513 ug/g) compared to controls (92 ug/g)
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immune system
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• iron content in spleen is markedly decreased vs wild-type
• at 8 months, splenic iron levels are decreased about 3-fold (273 ug/ g tissue vs 784 ug/g in wild-type)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hemochromatosis type 2B | DOID:0111032 |
OMIM:613313 |
J:119004 | |
