Phenotypes Associated with This Genotype

Genotype
MGI:3702614

ht2

• Allelic Composition: Sox1^tm1Vep/Sox1^tm2Vep
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:99610 )

N • generation and patterning of lateral ganglionic eminence (LGE) precursors is normal in mutants

abnormal neuronal migration ( J:99610 )

• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum

abnormal striatum morphology ( J:99610 )

• between E13 and 16, striatal mantle is more densely populated by proliferating precursors compared to wild-type

abnormal ventral striatum morphology ( J:99610 )

• migration or differentiation of ventral striatum (VS) neurons is disturbed in mutants

• at E13 to birth, the striatal bridges are absent

abnormal nucleus accumbens morphology ( J:99610 )

• staining for the markers Brn5 and Robo at E13 reveals a neural differentiation defect restricted in the region of the nucleus accumbens and olfactory tubercle (OT), and not the rest of the striatum

abnormal olfactory cortex morphology ( J:99610 )

• at E13 to birth, the striatal bridges and the olfactory tubercule (OT) layers are absent

cellular

abnormal neuronal migration ( J:99610 )

• early- and late-born neurons fail to migrate to appropriate positions to form ventral striatum