Phenotypes for Sox1 Sox2 MGI:3702615 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sox1^tm1Vep/Sox1^tm2Vep Sox2^tm1Vep/Sox2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox1^tm1Vep mutation (0 available); any Sox1 mutation (13 available)
Sox1^tm2Vep mutation (0 available); any Sox1 mutation (13 available)
Sox2^tm1Vep mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99610 )

• lethality associated with seizures is observed around weaning and is increased relative to Sox1-null mice

behavior/neurological

seizures ( J:99610 )

nervous system

seizures ( J:99610 )

abnormal olfactory cortex morphology ( J:99610 )

• embryos do not develop the olfactory tubercle (OT)

• at P10, OT neurons are detected in striatal mantle, but not in ventral striatum

vision/eye

microphthalmia ( J:99610 )

• mice are born with small eyes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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