Phenotypes Associated with This Genotype

Genotype
MGI:3702925

• Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Pcw
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:91277 )

• exhibit impaired hippocampus-dependent contextual fear learning at 3 months of age, showing reduced freezing behavior

• however, show normal cued fear learning, anxiety, motor coordination and shock threshold

nervous system

abnormal neuron differentiation ( J:91277 )

• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

cellular

abnormal neuron differentiation ( J:91277 )

• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:91277
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:91277