Phenotypes Associated with This Genotype

Genotype
MGI:3703437

hm1

• Allelic Composition: Alox12b^mmy/Alox12b^mmy
• Genetic Background: involves: A/J * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:119554 )

• lethality occurs within 24 hours of birth

homeostasis/metabolism

dehydration ( J:119554 )

• at E27.5 and 18.5, mice were dissected and weighed every hour for 6 hours; mutants lose between 21 and 27% of their body weight

impaired skin barrier function ( J:119554 )

• skin of newborns dessicates rapidly; at E17.5 and E18.5, fetuses do not display barrier acquisition

integument

impaired skin barrier function ( J:119554 )

• skin of newborns dessicates rapidly; at E17.5 and E18.5, fetuses do not display barrier acquisition

abnormal epidermis stratum corneum morphology ( J:119554 )

• epidermis has thickened compressed stratum corneum

dry skin ( J:119554 )

• skin of newborn mice rapidly dessicates and appears scaly

reddish skin ( J:119554 )

• affected mutants have red skin

scaly skin ( J:119554 )

• skin appears scaly after moisture loss

shiny skin ( J:119554 )

• mice are born with shiny skin