Phenotypes Associated with This Genotype

Genotype
MGI:3706544

• Allelic Composition: Ager^tm1.1Hyam/Ager^tm1.1Hyam; Tg(Ins2-Nos2)40Okam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating creatinine level ( J:116040 )

• serum creatinine is much lower than in Ager-sufficient transgenic mice at 8 months

hyperglycemia ( J:116040 )

• mice show sustained hyperglycemia (and display diabetes)

albuminuria ( J:116040 )

• urinary albumin/creatinine ratio is much lower than in wild-type transgenic mice or nontransgenic controls at 4 and 8 months

renal/urinary system

albuminuria ( J:116040 )

• urinary albumin/creatinine ratio is much lower than in wild-type transgenic mice or nontransgenic controls at 4 and 8 months

abnormal renal glomerulus morphology ( J:116040 )

glomerulosclerosis ( J:116040 )

• progression of sclerosis is attenuated in mice compared to Ager-sufficient transgenic mice

abnormal kidney size ( J:116040 )

• kidney weight as percentage of body weight is attenuated with Ager-deficiency; kidney weight as percentage of body weight is lower than in wild-type transgenic mice but percentage is still higher than non-transgenic (non-diabetic) mice at 4 and 8 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:116040