Phenotypes Associated with This Genotype

Genotype
MGI:3706545

• Allelic Composition: Tg(Ins2-Nos2)40Okam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:116040 )

• serum creatinine is much higher than in Ager-deficient transgenic mice at 8 months

hyperglycemia ( J:116040 )

• mice show sustained hyperglycemia (and display diabetes)

albuminuria ( J:116040 )

• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months

renal/urinary system

albuminuria ( J:116040 )

• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months

abnormal kidney morphology ( J:116040 )

• compared to Ager-null transgenic mice, kidneys show changes associated with diabetic nephropathy such as increased S100 protein levels and AGE deposits

increased kidney weight ( J:116040 )

• kidney weight composes a higher percentage of body weight compared to transgenic mice at 4 and 8 months

abnormal renal glomerulus morphology ( J:116040 )

• accumulation of advanced glycation end product (AGE) deposits in renal glomeruli is greater than in Ager-deficient transgenics

growth/size/body

increased kidney weight ( J:116040 )

• kidney weight composes a higher percentage of body weight compared to transgenic mice at 4 and 8 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:116040