Phenotypes Associated with This Genotype

Genotype
MGI:3706992

• Allelic Composition: Tlr4^tm1Aki/Tlr4^tm1Aki
• Genetic Background: B6.129P2-Tlr4^tm1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:121930 )

• mice are resistant to lethal shock induced by a synthetic lipopeptide analogue (Myr3CSK4)

respiratory system

respiratory system phenotype ( J:114985 )

N • no significant increase in inflammatory cells in the lungs over time

abnormal respiratory system morphology ( J:114985 )

• increased apoptosis in lungs

enlarged lung ( J:114985 )

• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months

abnormal pulmonary alveolar duct morphology ( J:114985 )

• enlarged air spaces distal to the terminal bronchioles

abnormal pulmonary alveolus morphology ( J:114985 )

• destruction of normal alveolar structures

abnormal pulmonary elastic fiber morphology ( J:114985 )

• elastin fibers are thin and fragmented in the lung parenchyma

• reduced elastase inhibitory activity in serum and in bronchoalveolar lavage fluid

abnormal respiratory system physiology ( J:147534 )

• bronchoalveolar protein levels are increased by ozone exposure

• ozone induced increase in bronchoalveolar cell counts is less than in controls at 3 hours but not 24 hours

abnormal airway responsiveness ( J:147534 )

• ozone exposure does not lead to hyperresponsiveness

increased lung compliance ( J:114985 )

• increased lung compliance

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:135620 )

• azoxymethane and dextran sodium sulfate treatment to induce tumor formation

• no visible polyploid lesions are seen in the intestine as they are in controls

• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid

decreased susceptibility to kidney reperfusion injury ( J:143920 )

• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury

neoplasm

decreased incidence of tumors by chemical induction ( J:135620 )

• azoxymethane and dextran sodium sulfate treatment to induce tumor formation

• no visible polyploid lesions are seen in the intestine as they are in controls

• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid

digestive/alimentary system

digestive/alimentary phenotype ( J:135620 )

N • level of colitis developed after azoxymethane and dextran sodium sulfate treatment is similar to controls

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:143920 )

• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury

abnormal nephron morphology ( J:143920 )

abnormal renal tubule morphology ( J:143920 )

abnormal renal tubule epithelium morphology ( J:143920 )

• fewer apoptotic tubular epithelial cells after ischemia/reperfusion injury as compared to controls except at 5 days after injury when apoptosis is elevated

• tubular epithelial cell proliferation is reduced 10 days after injury relative to controls

abnormal proximal convoluted tubule brush border morphology ( J:143920 )

• less brush border loss after ischemia/reperfusion injury as compared to controls

dilated renal tubule ( J:143920 )

renal tubular necrosis ( J:143920 )

• reduced tubular necrosis after ischemia/reperfusion injury as compared to controls

renal cast ( J:143920 )

• less cast formation after ischemia/reperfusion injury as compared to controls

growth/size/body

enlarged lung ( J:114985 )

• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:114985