Phenotypes Associated with This Genotype

Genotype
MGI:3707206

hm1

• Allelic Composition: Ciita^tm1.1Dim/Ciita^tm1.1Dim
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased dendritic cell number ( J:51885 )

• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced

decreased CD4-positive, alpha-beta T cell number ( J:51885 )

• numbers of CD4+CD8- tymocytes are reduced compared to wild-type

• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type

immune system

decreased dendritic cell number ( J:51885 )

• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced

decreased CD4-positive, alpha-beta T cell number ( J:51885 )

• numbers of CD4+CD8- tymocytes are reduced compared to wild-type

• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type

abnormal level of surface class II molecules ( J:51885 )

• macrophages from mutant mice fail to display class II molecules

• level of class II molecules in lymph nodes is less than in control littermates (by 3- to 5-fold)