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Phenotypes Associated with This Genotype
Genotype
MGI:3707972
Allelic
Composition
Disc1Rgsc1393/Disc1Rgsc1393
Genetic
Background
B6.Cg-Disc1Rgsc1393
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1Rgsc1393 mutation (2 available); any Disc1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• the time spent on the open arms of the elevated plus maze by homozygous mutant and wild-type mice is similar, indicating they experience similar anxiety levels
• performance in the Morris water maze is similar for homozygous mutant and wild-type mice, suggesting the mutation does not affect spatial learning or spatial memory
• homozygous mutant mice exhibit disruption in latent inhibition (LI) of fear conditioning by pre-training exposure to the conditioned neutral stimulus (CS; sound) without the noxious unconditioned stimulus (US; shock)
• the antipsychotic clozapine does not restore LI in these mice
• mutant mice that are not not pre-exposed to the unpaired neutral stimulus acquire a strong US/CS association
• in a working memory test using a discrete paired-trial variable-delay T-maze task, homozygous mutant mice make fewer correct choices than do wild-type mice at shorter (5 s and 10 s) but not longer (30 s) choice delay intervals
• homozygous mutant mice consume significantly less of a 10% sucrose solution relative to water consumed than do wild-type mice, consistent with low reward responsiveness
• the ability of homozygous mutants to taste sweetness is unimpaired, as demonstrated by the similarity of mutants' and controls' preferences for various sucrose concentrations
• in the forced swim test (FST), a test of depressive behavior, homozygous mutant mice spend significantly more time (p<0.05) than wild-type mice floating immobile; on day 2, heterozygous and wild-type mice also exhibit increased immobility, but homozygotes again spend significantly more time immobile
• although both bupropion and the phosphodiesterase 4 (PDE4) inhibitor rolipam diminish the immobility time of wild-type mice, only the antidepressant bupropion decreases the time homozygous mutant mice spend immobile
• in the sociability test, whereas wild-type mice spend significantly more time in a chamber with an unfamiliar mouse than in an unoccupied chamber, neither homozygous nor heterozygous mutant mice show such a preference
• in the social novelty test, whereas wild-type mice spend more time in a chamber with a new unfamiliar mouse than with one to which they previously have been introduced, both homozygous and heterozygous mutant mice show no such preference

nervous system
• magnetic resonance imaging (MRI) reveals that the brain volumes of homozygous and heterozygous mutant mice are 6% lower than those of wild-type mice
• MRI reveals contraction of the thalamus in homozygous and heterozygous mutant mice
• MRI reveals contraction of the entorhinal cortex in homozygous and heterozygous mutant mice
• MRI reveals contraction around the cerebral cortex, without alteration of white-matter tracts, in homozygous and heterozygous mutant mice
• MRI reveals contraction of the cerebellum in homozygous and heterozygous mutant mice
• mice homozygous for this mutation exhibit significantly lower prepulse inhibition (PPI; p<0.01), i.e., less reduction of the startle response following a prepulse, than do wild-type mice
• the antidepressant bupropion, a dopamine and norepinephrine reuptake inhibitor, abolishes the PPI deficit of homozygous mutants
• the typical antipsychotic haloperidol, a dopamine D2 receptor antagonist, fails to alleviate the PPI deficit in mice homozygous for this mutation
• the atypical antipsychotic clozapine, a combined dopamine D2 and serotonin receptor antagonist that increases PPI in wild-type mice, fails to alleviate the PPI deficit in homozygous mutant mice
• the phosphodiesterase 4 (PDE4) inhibitor rolipram does not affect the PPI in mice with this mutation
• in the absence of a prepulse, the amplitude of the acoustic startle response is similar in homozygous mutant and wild-type mice; the acoustic startle is unaffected by haloperidol, clozapine, bupropion or rolipram

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
melancholic depression DOID:1595 OMIM:608516
J:120634


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory