About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3707972
Allelic
Composition
Disc1Rgsc1393/Disc1Rgsc1393
Genetic
Background
B6.Cg-Disc1Rgsc1393
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1Rgsc1393 mutation (2 available); any Disc1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• the time spent on the open arms of the elevated plus maze by homozygous mutant and wild-type mice is similar, indicating they experience similar anxiety levels
• performance in the Morris water maze is similar for homozygous mutant and wild-type mice, suggesting the mutation does not affect spatial learning or spatial memory
• homozygous mutant mice exhibit disruption in latent inhibition (LI) of fear conditioning by pre-training exposure to the conditioned neutral stimulus (CS; sound) without the noxious unconditioned stimulus (US; shock)
• the antipsychotic clozapine does not restore LI in these mice
• mutant mice that are not not pre-exposed to the unpaired neutral stimulus acquire a strong US/CS association
• in a working memory test using a discrete paired-trial variable-delay T-maze task, homozygous mutant mice make fewer correct choices than do wild-type mice at shorter (5 s and 10 s) but not longer (30 s) choice delay intervals
• homozygous mutant mice consume significantly less of a 10% sucrose solution relative to water consumed than do wild-type mice, consistent with low reward responsiveness
• the ability of homozygous mutants to taste sweetness is unimpaired, as demonstrated by the similarity of mutants' and controls' preferences for various sucrose concentrations
• in the forced swim test (FST), a test of depressive behavior, homozygous mutant mice spend significantly more time (p<0.05) than wild-type mice floating immobile; on day 2, heterozygous and wild-type mice also exhibit increased immobility, but homozygotes again spend significantly more time immobile
• although both bupropion and the phosphodiesterase 4 (PDE4) inhibitor rolipam diminish the immobility time of wild-type mice, only the antidepressant bupropion decreases the time homozygous mutant mice spend immobile
• in the sociability test, whereas wild-type mice spend significantly more time in a chamber with an unfamiliar mouse than in an unoccupied chamber, neither homozygous nor heterozygous mutant mice show such a preference
• in the social novelty test, whereas wild-type mice spend more time in a chamber with a new unfamiliar mouse than with one to which they previously have been introduced, both homozygous and heterozygous mutant mice show no such preference

nervous system
• magnetic resonance imaging (MRI) reveals that the brain volumes of homozygous and heterozygous mutant mice are 6% lower than those of wild-type mice
• MRI reveals contraction of the thalamus in homozygous and heterozygous mutant mice
• MRI reveals contraction of the entorhinal cortex in homozygous and heterozygous mutant mice
• MRI reveals contraction around the cerebral cortex, without alteration of white-matter tracts, in homozygous and heterozygous mutant mice
• MRI reveals contraction of the cerebellum in homozygous and heterozygous mutant mice
• mice homozygous for this mutation exhibit significantly lower prepulse inhibition (PPI; p<0.01), i.e., less reduction of the startle response following a prepulse, than do wild-type mice
• the antidepressant bupropion, a dopamine and norepinephrine reuptake inhibitor, abolishes the PPI deficit of homozygous mutants
• the typical antipsychotic haloperidol, a dopamine D2 receptor antagonist, fails to alleviate the PPI deficit in mice homozygous for this mutation
• the atypical antipsychotic clozapine, a combined dopamine D2 and serotonin receptor antagonist that increases PPI in wild-type mice, fails to alleviate the PPI deficit in homozygous mutant mice
• the phosphodiesterase 4 (PDE4) inhibitor rolipram does not affect the PPI in mice with this mutation
• in the absence of a prepulse, the amplitude of the acoustic startle response is similar in homozygous mutant and wild-type mice; the acoustic startle is unaffected by haloperidol, clozapine, bupropion or rolipram

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
melancholic depression DOID:1595 OMIM:608516
J:120634


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory