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Phenotypes Associated with This Genotype
Genotype
MGI:3710322
Allelic
Composition		 Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2ctm1Bbd mutation (1 available); any Cdkn2c mutation (17 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (243 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:102702 )
• 4/4 of mice receiving 4 Gy radiation at P5 develop cerebellar tumors by 5 months of age

nervous system
increased medulloblastoma incidence ( J:102702 )
• 4/4 of mice receiving 4 Gy radiation at P5 develop cerebellar tumors by 5 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:102702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory