Phenotypes Associated with This Genotype

Genotype
MGI:3710359

• Allelic Composition: Serpina6^tm1Tew/Serpina6^tm1Tew
• Genetic Background: involves: 129/SvEmcTer * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating corticosterone level ( J:112974 )

• in anesthetized mice total corticosterone levels are reduced by 50% but the free fraction is increased by 10-fold

• similar to anesthetized mice, in non-anesthetized mice total corticosterone levels are reduced (9.6 +/- 2.4 ng/ml compared to 55.5 +/- 9.43 in wild-type mice) and free levels are increased (2.98+/-0.9ng/ml compared to 0.41+/-0.24ng/ml in wild-type mice)

• despite the increase in corticosterone levels, no differences are detected in serum or urine electrolyte, creatinine, glucose, insulin, or leptin levels

increased adrenocorticotropin level ( J:112974 )

• despite the increase in free corticosterone levels, a 300% increase in ACTH levels is seen (599.3+/-73.7pg/ml versus 238+/-62.3pg/ml in wild-type mice)

abnormal cytokine level ( J:112974 )

• injection of endotoxin leads to an increase in IL-1b levels in the lung

abnormal circulating cytokine level ( J:112974 )

• injection of endotoxin leads to an increase in serum granulocyte colony-stimulating factor levels

immune system

abnormal cytokine level ( J:112974 )

• injection of endotoxin leads to an increase in IL-1b levels in the lung

abnormal circulating cytokine level ( J:112974 )

• injection of endotoxin leads to an increase in serum granulocyte colony-stimulating factor levels

increased susceptibility to endotoxin shock ( J:112974 )

• injection of endotoxin leads to increased susceptibility to acute septic shock with 5 of 5 mice dying within the first 48 hours where as only 2 of 5 control mice had died

• injection of endotoxin also leads to an increase in granulocyte colony-stimulating factor and IL-1b levels and mononuclear cell infiltrate in the lung

behavior/neurological

decreased locomotor activity ( J:112974 )

liver/biliary system

liver/biliary system phenotype ( J:112974 )

N • despite the changes in corticosterone levels, liver morphology appears normal at E15.5

renal/urinary system

renal/urinary system phenotype ( J:112974 )

N • despite the changes in corticosterone levels, kidney morphology appears normal at E15.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
corticosteroid-binding globulin deficiency		DOID:0090030	OMIM:611489	J:112974