Phenotypes Associated with This Genotype

Genotype
MGI:3710485

tg1

• Allelic Composition: Tg(Myh6-Ccnd2)1Ljf/0
• Genetic Background: involves: C3HeB/FeJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:104622 )

• increase in the heart weight to body weight ratio

abnormal myocardial fiber physiology ( J:104622 )

• cardiomyocyte DNA synthesis is detected in hearts, unlike in controls

• myocardial injury (isoproterenol-induced hypertrophy) has no effect on the ventricular cardiomyocyte DNA synthesis that is observed in mutants

abnormal response to cardiac infarction ( J:104622 )

• mutants subjected to permanent coronary artery occlusion exhibit high levels of cardiomyocyte DNA synthesis compared to very low levels in controls after injury

decreased myocardial infarct size ( J:104622 )

• infract size in hearts is reduced and cardiomyocyte numbers are increased at 150 days after injury (coronary artery occlusion) but not at 7 days after injury

homeostasis/metabolism

abnormal response to cardiac infarction ( J:104622 )

• mutants subjected to permanent coronary artery occlusion exhibit high levels of cardiomyocyte DNA synthesis compared to very low levels in controls after injury

decreased myocardial infarct size ( J:104622 )

• infract size in hearts is reduced and cardiomyocyte numbers are increased at 150 days after injury (coronary artery occlusion) but not at 7 days after injury

growth/size/body

increased heart weight ( J:104622 )

• increase in the heart weight to body weight ratio