homeostasis/metabolism
|
• cerebellum and cerebrellum T4 content is reduced to 53% and 78%, respectively
• however, clearance from the blood and liver uptake is normal
|
|
• 34% reduction in serum T4 levels
|
|
• uptake of [125I]T3 in the brain is severely impaired
• cerebellum and cerebrellum T3 content is reduced to 61% and 66%, respectively
• however, clearance from the blood and liver uptake is normal
|
|
• 203% increase in serum T3 levels
|
nervous system
|
• unlike in human patients no reduction in brain size or brain morphology was observed
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Allan-Herndon-Dudley syndrome | DOID:0050631 |
OMIM:300523 |
J:120737 |