Phenotypes Associated with This Genotype

Genotype
MGI:3710763

• Allelic Composition: Tg(Prnp-ITM2B/APP695*42)A12Emcg/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:101023 )

• cored plaques can be observed as early as 3 months in molecular layer of cerebella of transgenic mice and becoming more pronounced with age; occasional extracellular plaques are seen in the entorhinal/piriform cortices and hippocampus at 6 months of age, but aren't consistently found until >12 months of age

• oldest mice show widespread pathology with cored and diffuse plaques in cerebellum, cortex, hippocampus, and olfactory bulb

• extracellular amyloid plaques show dense amyloid cores with radiating fibrils; many bundles of dystrophic neurites are observed at the periphery of these plaques

• compact plaques range from 38 um in diameter at 3 months to 58 um at 1-18 months

• tau pathology is not evident

• endogenous mouse Abeta is detected in some cored plaques and in diffuse deposits in older mice

abnormal forebrain morphology ( J:101023 )

• forebrain pathology only consistently develops after 12 months of age

gliosis ( J:101023 )

• reactive gliosis is associated with plaques

homeostasis/metabolism

amyloidosis ( J:101023 )

• Abeta1-42 peptide levels in 3-month old transgenic brains are ~1- to 1.5-fold higher than levels in 3- and 6-month oldTg(APPSWE)2576Kahs controls

amyloid beta deposits ( J:101023 )

• cored plaques can be observed as early as 3 months in molecular layer of cerebella of transgenic mice and becoming more pronounced with age; occasional extracellular plaques are seen in the entorhinal/piriform cortices and hippocampus at 6 months of age, but aren't consistently found until >12 months of age

• oldest mice show widespread pathology with cored and diffuse plaques in cerebellum, cortex, hippocampus, and olfactory bulb

• extracellular amyloid plaques show dense amyloid cores with radiating fibrils; many bundles of dystrophic neurites are observed at the periphery of these plaques

• compact plaques range from 38 um in diameter at 3 months to 58 um at 1-18 months

• tau pathology is not evident

• endogenous mouse Abeta is detected in some cored plaques and in diffuse deposits in older mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:101023