Phenotypes Associated with This Genotype

Genotype
MGI:3710766

• Allelic Composition: Tg(APPSWE)2576Kha/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

microgliosis ( J:159623 )

• at 24 months

amyloid beta deposits ( J:101023 , J:121703 , J:159623 )

• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)

• at 2 years (J:121703)

• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)

astrocytosis ( J:159623 )

• at 24 months

cardiovascular system

abnormal blood circulation ( J:119251 )

• after myocardin gene transfer to neocortical pial vessels in 16-month old mice, mice show significant reduction in cerebral blood flow response to whisker stimulation

hematopoietic system

microgliosis ( J:159623 )

• at 24 months

immune system

microgliosis ( J:159623 )

• at 24 months

homeostasis/metabolism

amyloidosis ( J:101023 )

• formic acid extractable Abeta40 and Abeta42 levels are dramatically elevated at 14.5 months compared to Tg(Prnp-ITM2B/APP695*42)A12Emcg mice

amyloid beta deposits ( J:101023 , J:121703 , J:159623 )

• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)

• at 2 years (J:121703)

• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:119251