Phenotypes Associated with This Genotype

Genotype
MGI:3711004

• Allelic Composition: Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}; Myf5^tm1(cre)Mrc/Myf5^tm1(cre)Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:120967 )

• about 8% of mice die by 2 months of age

neoplasm

increased tumor incidence ( J:120967 )

• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age

• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes

• small and potentially metastatic tumors are detected

• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors

• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors

increased sarcoma incidence ( J:120967 )

• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)

• myxoid and fibrous changes are observed

muscle

abnormal muscle development ( J:120967 )

• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent

• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal

growth/size/body

decreased body size ( J:120967 )

• about 8% of mice are born small

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synovial sarcoma		DOID:5485	OMIM:300813	J:120967