immune system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
|
• HLA-A2.1-restricted T cells from mice as young as 5 weeks of age respond to IGRP (islet-specific glucose-6-phophatase catalytic subunit-related protein) peptides
|
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
|
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets
|
• 55% of females develop type I diabetes by 30 weeks of age, with significantly accelerated onset compared with non transgenic littermates
|
hematopoietic system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
|
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
|
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:121685 |