Analysis Tools
vision/eye
endocrine/exocrine glands
 |
• lack palmar and volar sweat glands
|
anhidrosis
(
J:42660
)
|
|
• exhibit anhidrosis
|
respiratory system
|
|
• unable to keep nasal cavities clear, impairing air flow causing "snuffling"
|
|
|
• male mice lack submucosal glands
|
pigmentation
limbs/digits/tail
|
|
• dermal ridges on the paws are absent in all adults; EGF injection postnatally can induce dermal ridge and sweat gland formation
|
|
|
• lack palmar and volar sweat glands
|
|
|
• usually there are multiple sharp kinks at the tail tip
(J:249)
(J:12999)
|
skeleton
|
|
(J:5018)
(J:12999)
|
|
|
• often absent
|
short incisors
(
J:5018
)
|
|
|
|
|
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger
|
|
|
• crown of molars shows a simplified cusp pattern
|
|
|
• molars have 1-2 composite roots instead of the usual three roots
|
|
|
• third molar is often absent
(J:5018)
(J:12999)
|
small molars
(
J:5018
)
|
|
• molars are usually smaller than normal
|
|
|
• increase in enamel cover of the incisors
|
craniofacial
|
|
(J:5018)
(J:12999)
|
|
|
• often absent
|
short incisors
(
J:5018
)
|
|
|
|
|
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger
|
|
|
• crown of molars shows a simplified cusp pattern
|
|
|
• molars have 1-2 composite roots instead of the usual three roots
|
|
|
• third molar is often absent
(J:5018)
(J:12999)
|
small molars
(
J:5018
)
|
|
• molars are usually smaller than normal
|
|
|
• increase in enamel cover of the incisors
|
|
|
• unable to keep nasal cavities clear, impairing air flow causing "snuffling"
|
integument
|
|
• lack palmar and volar sweat glands
|
anhidrosis
(
J:42660
)
|
|
• exhibit anhidrosis
|
|
|
• hair does not develop behind the ears or on the tail
(J:249)
(J:12999)
|
|
|
(J:249)
(J:12999)
|
|
|
(J:249)
(J:12999)
|
|
|
• usually one rather than two supra-orbital vibrissa
|
|
|
• post-orbital sinus follicle and vibrissa are absent
|
growth/size/body
|
|
(J:5018)
(J:12999)
|
|
|
• often absent
|
short incisors
(
J:5018
)
|
|
|
|
|
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger
|
|
|
• crown of molars shows a simplified cusp pattern
|
|
|
• molars have 1-2 composite roots instead of the usual three roots
|
|
|
• third molar is often absent
(J:5018)
(J:12999)
|
small molars
(
J:5018
)
|
|
• molars are usually smaller than normal
|
|
|
• increase in enamel cover of the incisors
|
|
|
• unable to keep nasal cavities clear, impairing air flow causing "snuffling"
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypohidrotic ectodermal dysplasia | DOID:14793 | J:42660 | ||
