Phenotypes Associated with This Genotype

Genotype
MGI:3712286

• Allelic Composition: Mecp2^tm2Bird/Mecp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

♀ • at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

limb grasping ( J:118365 )

♀ • at 4 to 12 months of age

tremors ( J:118365 )

♀ • at 4 to 12 months of age

growth/size/body

obese ( J:118365 )

♀ • mice exhibit excess weight gain

nervous system

reduced long-term potentiation ( J:118365 )

♀ • mice develop a reduction in long term potentiation

respiratory system

abnormal breathing pattern ( J:118365 )

♀ • at 4 to 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:118365