Phenotypes Associated with This Genotype

Genotype
MGI:3712469

• Allelic Composition: Thbd^tm2Emc/Thbd^tm2Emc
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:118000 )

• during hypoxia 7 of 18 mice die with diffuse lung fibrin depositions compared to only one wild-type mouse

immune system

abnormal leukocyte physiology ( J:118000 )

• leukocyte accumulation in the lung is increased

hematopoietic system

abnormal leukocyte physiology ( J:118000 )

• leukocyte accumulation in the lung is increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thrombophilia		DOID:2452	OMIM:PS188050	J:118000