Phenotypes Associated with This Genotype

Genotype
MGI:3713117

• Allelic Composition: Hspg2^tm1.1Rdgr/Hspg2^tm1.1Rdgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:121855 )

N • mice do not show any obvious phenotype; no obvious differences in shape or mineralization of the long bones is seen compared to wild-type

abnormal long bone epiphyseal plate proliferative zone ( J:121855 )

• a subtle increase in interterritorial matrix vs cell ratio in proliferative zone of growth plate is observed compared to wild-type; stacking of cells is somewhat disorganized

abnormal long bone hypertrophic chondrocyte zone ( J:121855 )

• hypertrophic chondrocytes appear larger and rounder on average than wild-type cells; stacking of cells is somewhat disorganized

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Schwartz-Jampel syndrome 1		DOID:0090005	OMIM:255800	J:121855