Phenotypes Associated with This Genotype

Genotype
MGI:3713273

hm1

• Allelic Composition: Mrtfa^tm1Eno/Mrtfa^tm1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:111412 )

♀ • premature involution due to milk stasis

♀ • light increase in proliferation during involution, resulting in post-involution mammary gland structure that is not significantly different from controls

abnormal mammary gland growth during lactation ( J:111412 )

♀ • starting at day 4 of lactation, alveolar density is reduced and at day 12 alveoli are larger, less organized, and separated by adipocytes

♀ • however, mammary development during embryogenesis and pregnancy are normal

♀ • reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

abnormal mammary gland myoepithelium morphology ( J:111412 )

♀ • reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

pale mammary gland ( J:111412 )

♀ • mammary glands in lactating females at lactation day 12 are pale

abnormal lactation ( J:111412 )

♀ • pups raised by homozygous females show growth retardation by P4 and lethality by P20 despite normal maternal nurturing behavior

♀ • mammary glands in lactating females at lactation day 12 contain excess milk and are pale

galactostasis ( J:111412 )

♀ • milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner

abnormal mammary gland myoepithelium physiology ( J:111412 )

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

increased mammary gland apoptosis ( J:111412 )

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

integument

abnormal involution of the mammary gland ( J:111412 )

♀ • premature involution due to milk stasis

♀ • light increase in proliferation during involution, resulting in post-involution mammary gland structure that is not significantly different from controls

abnormal mammary gland growth during lactation ( J:111412 )

♀ • starting at day 4 of lactation, alveolar density is reduced and at day 12 alveoli are larger, less organized, and separated by adipocytes

♀ • however, mammary development during embryogenesis and pregnancy are normal

♀ • reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

abnormal mammary gland myoepithelium morphology ( J:111412 )

♀ • reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

pale mammary gland ( J:111412 )

♀ • mammary glands in lactating females at lactation day 12 are pale

abnormal lactation ( J:111412 )

♀ • pups raised by homozygous females show growth retardation by P4 and lethality by P20 despite normal maternal nurturing behavior

♀ • mammary glands in lactating females at lactation day 12 contain excess milk and are pale

galactostasis ( J:111412 )

♀ • milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner

abnormal mammary gland myoepithelium physiology ( J:111412 )

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

increased mammary gland apoptosis ( J:111412 )

♀ • massive apoptosis of myoepithelial cells is detected at lactation day 10

behavior/neurological

galactostasis ( J:111412 )

♀ • milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner