Phenotypes Associated with This Genotype

Genotype
MGI:3713294

• Allelic Composition: Gck^tm2Mgn/Gck⁺
• Genetic Background: 129S6/SvEvTac-Gck^tm2Mgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:121910 )

• ratio between plasma insulin and blood glucose level is significantly higher throughout the 120-minute period after glucose challenge

abnormal insulin secretion ( J:121910 )

• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

hyperglycemia ( J:121910 )

• fasted 4-week old mice display mild hyperglycemia

impaired glucose tolerance ( J:121910 )

• glucose regulation is impaired in mice

decreased glucokinase activity ( J:121910 )

• glucokinase activity is reduced ~43% compared to wild-type mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121910 )

N • islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet

abnormal insulin secretion ( J:121910 )

• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:121910