Analysis Tools
behavior/neurological
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• 18 day postpartum mice exhibit decreased preference for sucrose (anhedonia) compared to virgin mice or postpartum wild-type mice
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• 18 day postpartum mice exhibit decreased latency to immobility and increased immobility time in a forced swim test compared to virgin mice and postpartum wild-type mice
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• in a resident-intruder assay, postpartum mice exhibit increased digging, burrowing, and circling compared to virgin mice or postpartum wild-type mice without an increase in aggressive behavior
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• more pups, regardless of genotype, die of maternal neglect or pup cannibalism than in litters nurtured by wild-type mice
• however, treatment with THIP (a GABA A receptor delta subunit agonist) improves pup survival
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• postpartum female mice allow pups to disperse more than postpartum wild-type mice
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• postpartum mice fail to build a proper nest unlike postpartum wild-type mice
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nervous system
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• virgin and 18 day postpartum mice exhibit decreased tonic inhibition in dentate gyrus granule cells compared to virgin and postpartum wild-type mice
• however, mean conductance of synaptic GABA receptors is normal
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hearing/vestibular/ear
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• at 6 weeks of age, homozygotes show no signs of cochlear pathology, with normal hearing sensitivity, as determined by ABR/DPOAE assays across various test frequencies, and normal OHC efferent function, as assessed by measuring DPOAE suppression caused by efferent-bundle shocks
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| postpartum depression | DOID:9478 | J:145475 | ||
