Phenotypes Associated with This Genotype

Genotype
MGI:3714117

hm1

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp
• Genetic Background: FVB.Cg-Cdkn2a^tm1Rdp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens development ( J:110215 )

• lens fuses with retinal layers

cataract ( J:110215 )

• 94% of mice with either unilateral or bilateral cataracts

microphthalmia ( J:110215 )

• small eyes and abnormal in shape

• first observed embryonically

abnormal posterior eye segment morphology ( J:110215 )

persistent hyperplastic primary vitreous ( J:110215 )

• retrolental cell mass persists after 2 weeks of age

• hyaloid-artery like structures as late as 12 months of age

• primary vitreous membrane fails to regress and continues to develop

• primary vitreous membrane fuses to posterior capsule of the lens

abnormal retina neuronal layer morphology ( J:110215 )

• retinal folds

• progressive attachment of the retrolental mass to the neuroretina

abnormal retina photoreceptor morphology ( J:110215 )

• rosette-like arrangements of dysplastic photoreceptor cells

retina fold ( J:110215 )

• retinal folds are observed as early as E15.5

nervous system

abnormal retina photoreceptor morphology ( J:110215 )

• rosette-like arrangements of dysplastic photoreceptor cells