Phenotypes Associated with This Genotype

Genotype
MGI:3714371

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Tg(MMTV-cre)7Mul/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:61202 )

♀ • numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

♀ • mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

neoplasm

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

integument

abnormal mammary gland development ( J:61202 )

♀ • numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

♀ • mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:167180