Phenotypes Associated with This Genotype

Genotype
MGI:3714532

• Allelic Composition: Dp(16Lipi-Zbtb21)1Yey/0
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:121790 )

• only 38% of mice are alive at weaning

cardiovascular system

aorta coarctation ( J:121790 )

• seen in 1 of 30 embryos at E18.5

abnormal heart morphology ( J:121790 )

• at E18.5, about 37% of mice have heart defects including cleft of the mitral valve, atrial septal defect, perimembranous ventricular septum defect, conal ventricular septum defect, overriding of the aorta, narrowed outflow tract of the right ventricle, tetralogy of Fallot, double outlet right ventricle and coarcation of the aorta

double outlet right ventricle ( J:121790 )

• seen in one of 30 embryos at E18.5

overriding aortic valve ( J:121790 )

• seen in 2 of 30 embryos at E18.5

abnormal mitral valve morphology ( J:121790 )

• clefting seen in 3 of 30 embryos at E18.5

atrial septal defect ( J:121790 )

• seen in 4 of 30 embryos at E18.5

perimembraneous ventricular septal defect ( J:121790 )

• seen in 5 of 30 embryos at E18.5

subarterial ventricular septal defect ( J:121790 )

• seen in 2 of 30 embryos at E18.5

heart right ventricle outflow tract stenosis ( J:121790 )

• seen in 2 of 30 embryos at E18.5

digestive/alimentary system

abnormal intestine morphology ( J:121790 )

• at E18.5, 33% of mice have malrotation of the intestine

endocrine/exocrine glands

annular pancreas ( J:121790 )

• at E18.5, in about 26% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
annular pancreas		DOID:0060850	OMIM:167750	J:121790
tetralogy of Fallot		DOID:6419	OMIM:187500	J:121790