Phenotypes Associated with This Genotype

Genotype
MGI:3714749

• Allelic Composition: Mstn^tm1Sjl/Mstn^tm1Sjl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:40054 )

• abnormal body shape, with pronounced shoulders and hips

increased body size ( J:40054 )

• 30% larger

increased body weight ( J:75178 )

• significantly higher body weights at 4, 5, and 6 weeks of age

muscle

increased skeletal muscle fiber size ( J:40054 )

• mean fiber diameter of the tibilais cranialis muscle and gastrocnemius muscle is 7% and 22% larger, respectively, than in wild-type, indicating muscle cell hypertrophy

increased skeletal muscle fiber number ( J:40054 )

• at the widest portion of the tibialis cranialis muscle, the total cell number is 86% higher than in wild-type, indicating muscle cell hyperplasia

increased muscle weight ( J:40054 )

• individual muscles weight 2-3 times more than of wild-type

increased skeletal muscle mass ( J:40054 )

• large and widespread increase in skeletal muscle mass

increased skeletal muscle size ( J:75178 )

• gluteus muscle is larger at 8 and 12 weeks of age

adipose tissue

decreased total body fat amount ( J:75178 )

• at 12 weeks of age, show decreased fat depots

decreased epididymal fat pad weight ( J:75178 )

• weight is lighter at 8 and 12 weeks of age

decreased inguinal fat pad weight ( J:75178 )

• weight is lighter at 4, 8, and 12 weeks of age

decreased retroperitoneal fat pad weight ( J:75178 )

• weight is lighter at 12 weeks of age

decreased parametrial fat pad weight ( J:75178 )

• parametrial fat pads are lighter at 8 weeks of age

behavior/neurological

increased food intake ( J:75178 )

• food intake is higher, but only at 4 and 7 weeks of age

homeostasis/metabolism

decreased circulating leptin level ( J:75178 )

• serum leptin concentration is lower at 4 and 12 weeks of age but not at 8 weeks of age

abnormal lipid level ( J:75178 )

• at 12 weeks of age, lipid content is lower

liver/biliary system

decreased liver weight ( J:75178 )

• liver weights as a proportion of total body weight of mutants are less than those of wild-type at 4, 8, and 12 weeks of age

renal/urinary system

decreased kidney weight ( J:75178 )

• kidney weights as a proportion of total body weight of mutants are less than those of wild-type at 4 and 8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myostatin-related muscle hypertrophy		DOID:0111072	OMIM:614160	J:40054