Phenotypes Associated with This Genotype

Genotype
MGI:3714968

• Allelic Composition: Spi1^tm1.3Dgt/Spi1^tm1.3Dgt
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:90331 )

• mice are moribund or die by 3 to 8 months from fatal, aggressive neoplastic disease

neoplasm

increased T cell derived lymphoma incidence ( J:90331 )

• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice

increased leukemia incidence ( J:90331 )

• mice develop fatal, aggressive neoplastic disease similar to AML (acute myelogenous leukemia)

immune system

increased T cell derived lymphoma incidence ( J:90331 )

• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice

increased neutrophil cell number ( J:90331 )

• at 2 to 3 months of age, neutrophil numbers are increased relative to wild-type mice

decreased B cell number ( J:90331 )

• mice have fewer B lymphoid cells

abnormal spleen morphology ( J:90331 )

• abnormal architecture due to expansion of myeloid cells

enlarged spleen ( J:90331 )

• spleen is 1.5 to 2 times bigger than in wild-type mice

increased spleen weight ( J:90331 )

• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice

spleen hyperplasia ( J:90331 )

• due to expansion of myeloid cells

liver/biliary system

abnormal liver morphology ( J:90331 )

• abnormal architecture due to expansion of myeloid cells

increased liver weight ( J:90331 )

• leukemic mice livers weigh 3.0 to 7.2g compared to 1 to 1.5g in wild-type mice

liver hyperplasia ( J:90331 )

• due to expansion of myeloid cells

cellular

abnormal chromosome number ( J:90331 )

• trisomy 15 is common in mice with T cell lymphomas

hematopoietic system

increased T cell derived lymphoma incidence ( J:90331 )

• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice

abnormal definitive hematopoiesis ( J:90331 )

• moribund mice accumulate immature myeloid cells in bone marrow and spleen

abnormal proerythroblast morphology ( J:90331 )

• mice have fewer erythroid cells

increased neutrophil cell number ( J:90331 )

• at 2 to 3 months of age, neutrophil numbers are increased relative to wild-type mice

decreased B cell number ( J:90331 )

• mice have fewer B lymphoid cells

abnormal spleen morphology ( J:90331 )

• abnormal architecture due to expansion of myeloid cells

enlarged spleen ( J:90331 )

• spleen is 1.5 to 2 times bigger than in wild-type mice

increased spleen weight ( J:90331 )

• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice

spleen hyperplasia ( J:90331 )

• due to expansion of myeloid cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90331 )

• T cell lymphomas accompany myeloid leukemia and was the dominant disease in 2 mice

growth/size/body

increased liver weight ( J:90331 )

• leukemic mice livers weigh 3.0 to 7.2g compared to 1 to 1.5g in wild-type mice

liver hyperplasia ( J:90331 )

• due to expansion of myeloid cells

enlarged spleen ( J:90331 )

• spleen is 1.5 to 2 times bigger than in wild-type mice

increased spleen weight ( J:90331 )

• leukemic mice spleens weigh 600 to 1,600mg compared to 80 to 150mg in wild-type mice

spleen hyperplasia ( J:90331 )

• due to expansion of myeloid cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:90331