Phenotypes Associated with This Genotype

Genotype
MGI:3715252

• Allelic Composition: Tub^tub/Tub^tub
• Genetic Background: C57BL/6J-Tub^tub

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:13772 )

• increased body weight first becomes obvious at 3-4 months of age in males and 4-6 months in females

adipose tissue

increased total body fat amount ( J:13772 )

• the increase in weight is due to excess adipose tissue associated with all fat deposits

homeostasis/metabolism

increased circulating insulin level ( J:13772 )

• plasma immunoreactive insulin is increased to 2 times the normal prior to signs of obesity

• plasma insulin concentrations increase gradually through out life

• however, blood sugar levels are normal up to 9 months of age, the oldest mice tested

increased liver glycogen level ( J:13772 )

• liver glycogen is slightly increased

endocrine/exocrine glands

enlarged pancreatic islets ( J:13772 )

• islets of Langerhans are moderately enlarged

immune system

abnormal Langerhans cell physiology ( J:13772 )

• islets of Langerhans show indication of hyperactivity in the later stages

liver/biliary system

increased liver glycogen level ( J:13772 )

• liver glycogen is slightly increased

hepatic steatosis ( J:13772 )

• total liver lipids range from 2-3 times the normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:13772