About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3715252
Allelic
Composition
Tubtub/Tubtub
Genetic
Background
C57BL/6J-Tubtub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubtub mutation (3 available); any Tub mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight first becomes obvious at 3-4 months of age in males and 4-6 months in females

adipose tissue
• the increase in weight is due to excess adipose tissue associated with all fat deposits

homeostasis/metabolism
• plasma immunoreactive insulin is increased to 2 times the normal prior to signs of obesity
• plasma insulin concentrations increase gradually through out life
• however, blood sugar levels are normal up to 9 months of age, the oldest mice tested
• liver glycogen is slightly increased

endocrine/exocrine glands
• islets of Langerhans are moderately enlarged

immune system
• islets of Langerhans show indication of hyperactivity in the later stages

liver/biliary system
• liver glycogen is slightly increased
• total liver lipids range from 2-3 times the normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
J:13772


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory