growth/size/body
• increased body weight first becomes obvious at 3-4 months of age in males and 4-6 months in females
|
adipose tissue
• the increase in weight is due to excess adipose tissue associated with all fat deposits
|
homeostasis/metabolism
• plasma immunoreactive insulin is increased to 2 times the normal prior to signs of obesity
• plasma insulin concentrations increase gradually through out life
• however, blood sugar levels are normal up to 9 months of age, the oldest mice tested
|
• liver glycogen is slightly increased
|
endocrine/exocrine glands
• islets of Langerhans are moderately enlarged
|
immune system
• islets of Langerhans show indication of hyperactivity in the later stages
|
liver/biliary system
• liver glycogen is slightly increased
|
• total liver lipids range from 2-3 times the normal
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
obesity | DOID:9970 |
OMIM:601665 |
J:13772 |