mortality/aging
• begin to die at about 5 months of age; 50% die by around 11 months of age and none survive beyond 16 months of age
|
endocrine/exocrine glands
• 10- and 41-fold increase in the size of thyroid glands at 3-6 months of age and 12-15 months of age, respectively
|
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes
|
respiratory system
• respiratory distress due to the compression of the trachea by he enlarged thyroid glands
|
neoplasm
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
follicular thyroid carcinoma | DOID:3962 |
OMIM:188470 |
J:92629 |