Phenotypes Associated with This Genotype

Genotype
MGI:3716134

• Allelic Composition: Ins1^tm1Jja/Ins1^tm1Jja
• Genetic Background: NOD.129S2-Ins1^tm1Jja

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Severe insulitis in Ins2^tm1Jja/Ins2^tm1Jja mice and lack of insulitis in Ins1^tm1Jja/Ins1^tm1Jja mice

immune system

decreased susceptibility to autoimmune diabetes ( J:85309 )

• homozygotes are resistant to diabetes and insulitis development on the NOD background; whereas 13 of 15 wild-type NOD mice develop insulitis, only 1 of 19 homozygotes develop diabetes

• homozygous islets transplanted under the kidney capsule of recent onset NOD wild-type mice reversed the hyperglycemia and maintained euglycemia for a week or longer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:85309