Phenotypes Associated with This Genotype

Genotype
MGI:3716194

ot50

• Allelic Composition: Dmd^mdx/?
• Genetic Background: B6.B10ScSn-Dmd^mdx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:85088 )

• muscles contain occasional patches of pale tissue which are primarily connective tissue

abnormal skeletal muscle fiber morphology ( J:85088 )

• when mice are injected with the diazo dye EBD, dye is taken up by damaged muscle fibers to varying degrees, but preferentially into the hindlimb; uptake occurs because of focal breakdown of plasmalemma which is an early event in necrosis

• muscles are not stained homogeneously, but streaks of dye representing damaged muscle fibers are observed in the muscle fibers of the diaphragm and gluteus maximus; damage is less severe than in Fgf2/Fgf6/Dmd triple mutants

dystrophic muscle ( J:85088 )

• mutants show dystrophic changes to the muscle fibers, although less severely than Fgf2/Fgf6/Dmd triple mutants