Phenotypes Associated with This Genotype

Genotype
MGI:3716195

cx31

• Allelic Composition: Dmd^mdx/?; Fgf6^tm1Thbr/Fgf6^tm1Thbr
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal spine curvature ( J:42574 )

• dorso-ventral curvature of the spine

muscle

muscle phenotype ( J:42574 )

N • no clinical signs of severe dystrophy for up to 6 months

abnormal epaxial muscle morphology ( J:42574 )

• back and body wall musculature show changes similar to diaphragm but less uniformly and more focally distributed

abnormal hypaxial muscle morphology ( J:42574 )

• muscle changes similar to diaphragm but less uniformly and more focally distributed

abnormal diaphragm morphology ( J:42574 )

• pronounced increase in collagen

• increase in mononuclear cells

• unusually small myotubes with very few centrally located nuclei

dystrophic muscle ( J:85088 )

• changes are not enhanced compared to Dmd mutants

myopathy ( J:42574 )

• severe myopathy observed in diaphragm, limb muscles, and back muscles