Phenotypes Associated with This Genotype

Genotype
MGI:3716968

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:103407 )

• following cre-adenovirus treatment, a subset of tumors are highly invasive and grow into the hilus, heart, and overlying pleura

• following cre-adenovirus treatment, lymph node metastases are present in over 50% of mice

increased adenocarcinoma incidence ( J:103407 )

• at 19 weeks following cre-adenovirus treatment, sinonasal adenocarninomas develop in 14% of mice

decreased incidence of induced tumors ( J:154041 )

• mice infected with low-titre (5X10³) lentiviruses expressing Cre and Nfkbia have either a single lung adenocarcinoma or none at all

• mice infected with high-titre (5X10⁴) lentiviruses expressing Cre and Nfkbia have 6-22 lung adenocarcinomas detected per mouse

increased lung tumor incidence ( J:103407 )

• following cre-adenovirus treatment, all mice develop primary lung tumors that are similar to those found in Kras^tm4Tyj Trp53^tm1Brn heterozygotes

increased lung adenoma incidence ( J:103407 , J:203686 )

• at 6 weeks following cre-adenovirus treatment, mice have lesions ranging from atypical adenomatous hyperplasia to small adenomas that are larger than in Kras^tm4Tyj Trp53^tm1Brn heterozygotes (J:103407)

• lung adenocarcinomas cover 11% of lung area 6 weeks after administration of a Cre-recombinase expressing adenovirus (J:203686)

increased lung adenocarcinoma incidence ( J:103407 , J:154041 , J:195492 )

• following cre-adenovirus treatment, all mice develop advanced pulmonary adenocarinomas (J:103407)

• following cre-adenovirus treatment, multiple tumors are present ranging from well-defined tumors to advanced highly dysplastic lesions containing large sheets of dysplastic cells, abnormal mitoses, and multinucleated giant cells (J:103407)

• seventeen weeks after infection with low-titre (5X10³) cre lentiviruses, an average of 30 lung adenocarcinomas are detected per mouse (J:154041)

• seventeen weeks after infection with high-titre (5X10⁴) cre lentiviruses, 90-131 lung adenocarcinomas are detected per mouse (J:154041)

• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase (J:195492)

• tumor growth is reduced to a similar extent following either two 7.3 Gy fractions of radiation therapy or a single 11.6 Gy fraction (J:195492)

• tumors incorporate high levels of BrdU 4 hours after radiation treatment similarly to unirradiated tumors, indicating lack of an intact G1 cell-cycle checkpoint (J:195492)

mortality/aging

premature death ( J:103407 )

• mice do not survive to 26 weeks post cre-adenovirus treatment in contrast to Kras^tm4Tyj Trp53^tm1Brn heterozygous mice

respiratory system

increased lung tumor incidence ( J:103407 )

• following cre-adenovirus treatment, all mice develop primary lung tumors that are similar to those found in Kras^tm4Tyj Trp53^tm1Brn heterozygotes

increased lung adenoma incidence ( J:103407 , J:203686 )

• at 6 weeks following cre-adenovirus treatment, mice have lesions ranging from atypical adenomatous hyperplasia to small adenomas that are larger than in Kras^tm4Tyj Trp53^tm1Brn heterozygotes (J:103407)

• lung adenocarcinomas cover 11% of lung area 6 weeks after administration of a Cre-recombinase expressing adenovirus (J:203686)

increased lung adenocarcinoma incidence ( J:103407 , J:154041 , J:195492 )

• following cre-adenovirus treatment, all mice develop advanced pulmonary adenocarinomas (J:103407)

• following cre-adenovirus treatment, multiple tumors are present ranging from well-defined tumors to advanced highly dysplastic lesions containing large sheets of dysplastic cells, abnormal mitoses, and multinucleated giant cells (J:103407)

• seventeen weeks after infection with low-titre (5X10³) cre lentiviruses, an average of 30 lung adenocarcinomas are detected per mouse (J:154041)

• seventeen weeks after infection with high-titre (5X10⁴) cre lentiviruses, 90-131 lung adenocarcinomas are detected per mouse (J:154041)

• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase (J:195492)

• tumor growth is reduced to a similar extent following either two 7.3 Gy fractions of radiation therapy or a single 11.6 Gy fraction (J:195492)

• tumors incorporate high levels of BrdU 4 hours after radiation treatment similarly to unirradiated tumors, indicating lack of an intact G1 cell-cycle checkpoint (J:195492)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:103407 , J:154041 , J:195492 , J:203686