Analysis Tools
mortality/aging
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• 32% of mice die by week 2
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skeleton
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• abnormal neural crest derived and thoracic skeleton
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• 55% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones
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• increases in the gaps between frontal bones
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• 78% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline
|
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• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
|
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• 44% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum
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renal/urinary system
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• kidney is swollen in sections and blood filled
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• glomeruli are often degraded
• excess smooth muscle cells are found in the glomeruli
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small kidney
(
J:117491
)
pale kidney
(
J:117491
)
hematopoietic system
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• by week 6
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• by week 6
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• by week 6
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• an increase in immature red blood cells is observed compared to wild-type mice
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homeostasis/metabolism
cardiovascular system
hemorrhage
(
J:117491
)
|
• at E11.5-E18.5
|
muscle
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• excess smooth muscle cells are found in the glomeruli
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immune system
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• kidney is swollen in sections and blood filled
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craniofacial
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• 55% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones
|
|
• increases in the gaps between frontal bones
|
|
• 78% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline
|
|
• irregularities in fusion persist into adulthood
|
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• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
|
broad snout
(
J:117491
)
|
• snout is shorter and wider than in wild-type mice
|
short snout
(
J:117491
)
|
• snout is shorter and wider than in wild-type mice
|
digestive/alimentary system
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• irregularities in fusion persist into adulthood
|
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• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
|
growth/size/body
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• irregularities in fusion persist into adulthood
|
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• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
|
broad snout
(
J:117491
)
|
• snout is shorter and wider than in wild-type mice
|
short snout
(
J:117491
)
|
• snout is shorter and wider than in wild-type mice
|
respiratory system
