Phenotypes Associated with This Genotype

Genotype
MGI:3717196

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Eno2-APOE_i3)1Rabr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:100975 )

N • no alterations in passive avoidance learning are observed

abnormal spatial learning ( J:100975 )

• 6-month old female mice show significant impairment in learning in the Morris water maze paradigm; mice display no improvement over four consecutive trials

enhanced coordination ( J:100975 )

• mice perform better than other genotypes and controls in the rotorod test, displaying a significantly increased latency to fall from the rod

nervous system

abnormal nervous system physiology ( J:55835 , J:100975 )

• after injection of 18 mg/kg kainic acid, mice show no disruption of hippocampal axons, whereas wild-type show significant loss of synaptophysin-positive neocortical presynaptic terminals (J:55835)

• mice do not show the same age dependent loss of neocortical and hippocampal presynaptic terminals and neuronal dendrites as Apoe-null and Apoe-null, Apoe3-trangenic mice (J:55835)

• age-related neuronal pathologies observed in Apoe-deficient mice are prevented by transgene expression (J:100975)