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Phenotypes Associated with This Genotype
Genotype
MGI:3717196
cx1
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APOE_i3)1Rabr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(Eno2-APOE_i3)1Rabr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no alterations in passive avoidance learning are observed
• 6-month old female mice show significant impairment in learning in the Morris water maze paradigm; mice display no improvement over four consecutive trials
• mice perform better than other genotypes and controls in the rotorod test, displaying a significantly increased latency to fall from the rod

nervous system
• after injection of 18 mg/kg kainic acid, mice show no disruption of hippocampal axons, whereas wild-type show significant loss of synaptophysin-positive neocortical presynaptic terminals (J:55835)
• mice do not show the same age dependent loss of neocortical and hippocampal presynaptic terminals and neuronal dendrites as Apoe-null and Apoe-null, Apoe3-trangenic mice (J:55835)
• age-related neuronal pathologies observed in Apoe-deficient mice are prevented by transgene expression (J:100975)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory