Analysis Tools
cellular
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• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal
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azoospermia
(
J:123057
)
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• no spermatozoa are detected at 8 weeks of age
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• spermatogenesis is arrested at meiosis I
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reproductive system
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• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal
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azoospermia
(
J:123057
)
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• no spermatozoa are detected at 8 weeks of age
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• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected
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• spermatogenesis is arrested at meiosis I
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• at 8 weeks of age
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• at 8 weeks of age
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• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
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• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
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small testis
(
J:123057
)
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• at 8 weeks of age, mutant testes are smaller than wild-type
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• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
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cryptorchism
(
J:123057
)
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• mutant testes are located intra-abdominally
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• hemizygous mutant males display female external genitalia
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growth/size/body
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• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age
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homeostasis/metabolism
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• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates
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endocrine/exocrine glands
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• at 8 weeks of age
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• at 8 weeks of age
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• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
|
|
|
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
|
small testis
(
J:123057
)
|
|
• at 8 weeks of age, mutant testes are smaller than wild-type
|
|
|
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
|
cryptorchism
(
J:123057
)
|
|
• mutant testes are located intra-abdominally
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| androgen insensitivity syndrome | DOID:4674 |
OMIM:300068 |
J:123057 | |
