Phenotypes Associated with This Genotype

Genotype
MGI:3717256

• Allelic Composition: Ar^tm1.1Jdz/Y
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

short perineum ( J:122327 )

♂ • short ano-genital distance at 8 weeks of age

absent prostate gland ( J:122327 )

♂

absent seminal vesicle ( J:122327 )

♂

abnormal testis morphology ( J:122327 )

♂ • immature testes at 8 weeks of age

decreased testis weight ( J:122327 )

♂ • at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice

cryptorchism ( J:122327 )

♂ • testes are incompletely descended

absent scrotum ( J:122327 )

♂

absent epididymis ( J:122327 )

♂

homeostasis/metabolism

decreased circulating testosterone level ( J:122327 )

♂ • at 8 weeks of age, serum testosterone is reduced by 75% compared to in wild-type mice

digestive/alimentary system

short perineum ( J:122327 )

♂ • short ano-genital distance at 8 weeks of age

endocrine/exocrine glands

absent prostate gland ( J:122327 )

♂

absent seminal vesicle ( J:122327 )

♂

abnormal testis morphology ( J:122327 )

♂ • immature testes at 8 weeks of age

decreased testis weight ( J:122327 )

♂ • at 8 weeks of age, testis weight is reduced by 95% compared to wild-type mice

cryptorchism ( J:122327 )

♂ • testes are incompletely descended

growth/size/body

growth/size/body region phenotype ( J:122327 )

♂N • at 8 weeks of age, mutant males are overtly healthy with normal physical activity and normal body weights relative to control littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
androgen insensitivity syndrome		DOID:4674	OMIM:300068	J:122327