Phenotypes Associated with This Genotype

Genotype
MGI:3717577

• Allelic Composition: Tg(Thy1-APPLon)2Vln/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:53800 )

• 47.1% of animals died by 180 days of age; mortality by 360 days is 70.6% compared to 4.3% in controls

nervous system

seizures ( J:53800 )

• less than 15% of mice older than 6 months display spontaneous seizures

amyloid beta deposits ( J:53800 , J:64209 , J:93635 )

• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)

• mice younger than 12 months do not exhibit amyloid deposits (J:53800)

• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)

• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)

cerebral amyloid angiopathy ( J:93635 )

• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months

abnormal subiculum morphology ( J:93635 )

• by 15 months, subiculum is almost totally covered with diffuse and senile plaques

abnormal neurite morphology ( J:93635 )

• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice

reduced long-term potentiation ( J:53800 , J:87229 )

• tetanic stimulation in hippocampal brain slices triggers significantly impaired LTP; LTP progressively decreases in brain slices (J:87229)

behavior/neurological

abnormal response to new environment ( J:53800 )

• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age

hyperactivity ( J:53800 )

• mice exhibit increased episodes of agitation and spontaneous activity by 8 weeks of age onward

seizures ( J:53800 )

• less than 15% of mice older than 6 months display spontaneous seizures

homeostasis/metabolism

amyloidosis ( J:64209 , J:87229 )

• in brains of 10-12 month-old mice, diffuse and senile amyloid plaques are present and increase exponentially with age (J:87229)

amyloid beta deposits ( J:53800 , J:64209 , J:93635 )

• diffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptidediffuse amyloid plaques and compact neuritic plaques are detected in all mice 13-18 months old, most abundant in the hippocampus and cortex while occasionally seen in the thalamus, fimbria, external capsule, pontine nuclei, and white matter; plaques contain high amounts of the Abeta 42 peptide (J:53800)

• mice younger than 12 months do not exhibit amyloid deposits (J:53800)

• levels of plaque peptides extracted with guanidinium hydrochloride increase exponentially in mutants >15 months of age; plaque associated peptides are not detected in brains of mice at 6-9 months of age (J:64209)

• subiculum region of brain is loaded amyloid deposits starting at 10 months of age (J:93635)

cerebral amyloid angiopathy ( J:93635 )

• amyloid deposits are found in the parenchyma and in cortical and leptimenigeal arterioles in brains at 16 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:93635