Phenotypes Associated with This Genotype

Genotype
MGI:3717625

hm1

• Allelic Composition: Cacna1e^tm1.1Tsch/Cacna1e^tm1.1Tsch
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased glucagon secretion ( J:101873 )

• following carbachol treatment, glucagons release is impaired

• in vitro, Langerhan's islets fail to suppress glucagons secretion following elevated glucose levels

decreased insulin secretion ( J:95636 )

• following glucose stimulation, insulin secretion is reduced

• following glucose stimulation, secretion from Langerhan's islets is reduced

increased circulating glucose level ( J:101873 )

• serum glucose levels are increased to 133+/-4 mg/dl compared to 123+/-3 mg/dl in wild-type mice

hyperglycemia ( J:95636 )

• younger mice exhibit an attenuated hyperglycemic stress response

impaired glucose tolerance ( J:95636 )

• at 10 weeks, glucose tolerance is impaired

• impaired glucose response is partially compensated with age

decreased physiological sensitivity to xenobiotic ( J:101873 )

• following carbachol treatment, glucagon release is impaired relative to controls

endocrine/exocrine glands

decreased glucagon secretion ( J:101873 )

• following carbachol treatment, glucagons release is impaired

• in vitro, Langerhan's islets fail to suppress glucagons secretion following elevated glucose levels

decreased insulin secretion ( J:95636 )

• following glucose stimulation, insulin secretion is reduced

• following glucose stimulation, secretion from Langerhan's islets is reduced

growth/size/body

increased body weight ( J:101873 )

• mice are slightly heavier weighing 29.7g+/-0.5g compared to wild-type mice that weigh 28.3g+/-0.4g