Analysis Tools
behavior/neurological
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• no evidence of auditory response at 21 to 30 days of age to sound
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• can not swim on the surface of water or in a coordinated manner
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head bobbing
(
J:13131
)
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• vertical movement of head with the nose maintained high momentarily
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• whirling rapidly in circles of small diameter continuously for a long time by approximately 14 days of age
• no pronounced preference for right or left turning
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• beginning at approximately 10 days of age mutant mice first display backing or crab-like movements
• occasional running in circles
• figure eight movements
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hearing/vestibular/ear
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• the hair cells and the supporting cells start to degenerate by two weeks of age
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• although the organ of Corti develops normally, degeneration is found by the second week of life
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• after two month
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• the tectorial membrane is thickened at 12 days of age
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• cristae ampullares degenerate after eight months of age
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• by 6 th weeks
• macula of the utriculus remains unaffected
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• cyclostat assessment suggests that these mutants do not develop rotational dizziness
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nervous system
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• the hair cells and the supporting cells start to degenerate by two weeks of age
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• by four weeks of age
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• a reduction of the average cell size in mice older than 200 days
• contains about the same number of cells and the range of cell sizes, however, there are much less large and more small cells
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