Phenotypes Associated with This Genotype

Genotype
MGI:3718057

• Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0
• Genetic Background: B6.129S6-Dp(16Cbr1-Fam3b)1Rhr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:121764 )

N • mice perform similar to control mice in a Morris water maze with a visible or hidden platform and have normal long term potentials

cellular

abnormal brain ependyma motile cilium physiology ( J:241597 )

• cilia beating frequency and cilia beating angle are decreased

nervous system

abnormal brain ependyma motile cilium physiology ( J:241597 )

• cilia beating frequency and cilia beating angle are decreased

abnormal brain morphology ( J:241597 )

• whole brain volume is larger

• however, neurogenesis in adult brain is not decreased

• the cerebral aqueduct is not affected, with normal aqueduct of Sylvius

• cortical thickness is enlarged, particularly in the medial part of the brain

dilated lateral ventricle ( J:241597 )

• lateral brain ventricle volumes are larger at 3 months of age, increased by 63.8%

• other (3rd and 4th) ventricles show trends of enlargement

enlarged hippocampus ( J:241597 )

• hippocampal area is enlarged, particularly in the medial part of the brain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:241597