Phenotypes Associated with This Genotype

Genotype
MGI:3718076

• Allelic Composition: Tg(PDGFB-MAPT*V337M)1Atak/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

tau protein deposits ( J:100964 )

• in 4-15 month old transgenic mice, there is significant accumulation of SDS-insoluble tau protein in hippocampi, compared to wild-type mice

abnormal neuron morphology ( J:100964 )

• abnormal neurons bearing paired helical filament epitopes are observed in transgenic mice; neurons are smaller and convex in appearance relative to wild-type neurons

hippocampal neuron degeneration ( J:100964 )

• irregularly-shaped neurons in transgenic mice show characteristics of degenerating neurons, including RNA-accumulation in the cytoplasm, a swollen Golgi network, ruffled plasma and nuclear membranes, and straight fibrils in the cytoplasm similar to those associated with neurofibrillary tangles in human disease

loss of hippocampal neurons ( J:100964 )

• the irregularly shaped neurons appear to undergo cell death after the accumulation of phosphorylated tau and RNA, but do not show normal signs of apoptotic death

abnormal nervous system electrophysiology ( J:100964 )

• Schaffer collateral-evoked neural response in hippocampal slices is attenuated compared to controls; propagation patterns of neural activity is weaker, producing less voltage spread and smaller amplitudes relative to control slices

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:100964
frontotemporal dementia		DOID:9255	OMIM:600274	J:100964