Phenotypes Associated with This Genotype

Genotype
MGI:3719054

cx45

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺; Terc^tm1Rdp/Terc^tm1Rdp
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:120065 )

• 84% of early generation mutants succumb to tumors with a median tumor-free latency of 71.6 weeks

• late generation mutants show a decrease in percent tumor death and an increase in tumor-free latency, from 84% to 20% and 71.6-104.9 weeks

increased lymphoma incidence ( J:120065 )

• 19% and 23% of early generation and late generation mutants, respectively, develop lymphomas

increased sarcoma incidence ( J:120065 )

• 35% and 39% of early generation and late generation mutants, respectively, develop histocytic sarcomas

• 20% and 23% of early generation and late generation mutants, respectively, develop soft tissue sarcomas