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Phenotypes Associated with This Genotype
Genotype
MGI:3719087
cx4
Allelic
Composition		 Sox8tm1Weg/Sox8tm1Weg
Sox9tm2.1Crm/Sox9+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2.1Crm mutation (0 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:89368 )
• at E15.5, male mice have fewer seminiferous tubules
abnormal primary sex determination ( J:89368 )
• 3 of 3 mice exhibit abnormal sex chord development and a clearly outlined coelomic vessel
sex reversal ( J:89368 )
• at E15.5, male mice have areas resembling an ovary

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:89368 )
• at E15.5, male mice have fewer seminiferous tubules

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory