Phenotypes Associated with This Genotype

Genotype
MGI:3719353

• Allelic Composition: Gadd45a^tm1Ajf/Gadd45a^tm1Ajf; Xpc^tm1Ecf/Xpc^tm1Ecf
• Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:101421 )

• at 24 months of age, only 28% of mutants are alive compared to 43% of wild-type

neoplasm

increased metastatic potential ( J:101421 )

• some mutants exhibit malignant adenocarcinoma with metastasis to adjacent lymph nodes

increased lung tumor incidence ( J:101421 )

• 100% of mutants develop lung tumors by 24 months of age; display a full range of lung lesions, ranging from mild atypia and hyperplasia to malignant adenocarcinoma with metastasis to adjacent lymph nodes

increased lung adenoma incidence ( J:101421 )

increased lung adenocarcinoma incidence ( J:101421 )

• majority of mutants develop lung adenocarcinomas coincident with adenomas

respiratory system

increased lung tumor incidence ( J:101421 )

• 100% of mutants develop lung tumors by 24 months of age; display a full range of lung lesions, ranging from mild atypia and hyperplasia to malignant adenocarcinoma with metastasis to adjacent lymph nodes

increased lung adenoma incidence ( J:101421 )

increased lung adenocarcinoma incidence ( J:101421 )

• majority of mutants develop lung adenocarcinomas coincident with adenomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:101421