Phenotypes for Cacna1f MGI:3720002 MGI Mouse

vision/eye

abnormal retina rod bipolar cell morphology ( J:123811 )

• rod bipolar cell dendrites extend beyond the outer plexiform layer into the outer nuclear layer, in some cases, dendrites reach the retinal pigment epithelium

abnormal retina ganglion cell morphology ( J:123811 )

• ON-center cells exhibit reduced spontaneous activity to a photopic adapting stimulus as compared to wild-type

• ON-center cells have a reduced dynamic range, although basic center-surround organization is retained

abnormal retina horizontal cell morphology ( J:123811 )

• horizontal cell dendrites extend beyond the outer plexiform layer into the outer nuclear layer reaching the retinal pigment epithelium

abnormal retina outer nuclear layer morphology ( J:123811 )

• bipolar and horizontal cells extend ectopic processes into the outer nuclear layer

• small, diffuse punctate staining is observed in the outer nuclear layer using the presynaptic ribbon marker, Ribeye

disorganized retina outer plexiform layer ( J:123811 )

• in adult mice OPL is disorganized, however, other retinal layers appear normal

• horseshoe shaped structures visualized by immunolabeling using the presynaptic ribbon marker, Ribeye, are missing in mutants and are replaced by small, diffuse punctate staining

abnormal cone electrophysiology ( J:123811 )

• light adapted ERGs are reduced in amplitude and have slower kinetics as compared to control

• implicit time of the b-wave is delayed

• cone ERG amplitude has a distinctive waveform as compared to control

abnormal rod electrophysiology ( J:123811 )

• b-wave is markedly reduced through out the stimulus range in dark-adapted electroretinograms (ERG) in adult mice